Detection of gene rearrangements:

Gene rearrangement test using the 5’/3’ ratioing allows large scale screening of many leukemias and various types of cancers in which gene rearrangements due to chromosome translocations are the causative factors of the altered biological functions leading to cancerous transformation. Gene rearrangements are silent using current chip technology, aside from indirect consequences manifested in gene expression levels. The developed SAT technology renders gene rearrangements detectible, simultaneously within many genes. This is a unique feature of this method, currently no other technology provides the same information. The empirical fingerprint obtained via advanced cluster analysis is made possible by the developed FCAP Array software. The technology promises new insights and provides effective and simple tools widely applicable in routine clinical diagnostic work.

The test has been elaborated for the MLL gene.